Dr. Croyle's research focuses on the use of viruses for gene delivery and vaccine applications. The genes which make the virus infectious and allow it to cause disease are removed and replaced with a therapeutic gene. Viruses commonly employed in these strategies are adenoviruses (which naturally cause respiratory infections in humans), adeno-associated viruses (which cause no known disease in humans), and lentiviruses (which are related to the Human Immunodeficiency Virus). Specific research interests of the Croyle Lab are:
-Masking and predicting the immune response against recombinant viruses and transgene products.
-Molecular mechanisms of changes in drug metabolism during viral infection.
-In Vitro/In Vivo testing of formulations/delivery methods for gene therapy.
-Developments of large-scale production methods of viral for vaccines and gene therapy