Miller's general research interests lie in the confluence of GIScience, integration of GIS and remote sensing, and environmental/ecological modeling. Her specific research focus is in the application area of species distribution modeling (SDM), and much of her previous work has involved conducting extensive model comparisons, representing spatial accuracy, and incorporating spatial autocorrelation in SDM. Current research investigates the effects that spatial structure, scale and sampling strategies have on SDM using simulated data; using SDM to investigate the effects of climate change; and using spatial simulation to analyze (animal) species movement and interaction.