It is estimated that, for every new drug that reaches the market place, more than 8,000 potential drug candidates were synthesized, tested to varying extents, and judged to be unsuitable. Not surprisingly, the pharmaceutical industry is extremely interested in computer-based methods for improving the efficiency of the drug discovery process. The primary mission of their Laboratory for Molecular Graphics and Theoretical Modeling is to develop novel theory and software for computer-assisted drug design (CADD). They address both of the fundamental aspects of drug action: transport to the biophase and interaction with the receptor. Research assistants acquire a broad background in physical chemistry, computational chemistry, numerical analysis and computer programming and utilize state-of-the-art hardware and software in a laboratory supported, in part, by the proceeds resulting from the commercial distribution of software which they have developed.