Research interests in my laboratory focus on translational chemical biology using an innovative metabolomics-based systems biology approach for metabolic biomarker discovery. My laboratory combines i) high-throughput screening measurements, ii) magnetic resonance spectroscopy and mass spectrometry-based metabolomics, iii) metabolic flux analysis and iv) other omic data to gain a better bio-mechanistic understanding of the effects of combined drug treatment and nutrient modulation in cancer metabolism. I have been instrumental in identifying and validating biomarkers of oncogenic transformation and response to targeted therapies in several disease settings including leukemias, oral cancer, and multiple myeloma. My lab is constantly engaged in developing and optimizing data acquisition and analysis methodologies as well as data mining procedures Capitalizing on this expertise, my lab is currently involved in several collaborative projects that aim to target the metabolome and define new treatment strategies in cancer and non-cancer conditions.