Focused ultrasound amygdala neuromodulation for the mechanistic treatment of affective disorders (One Mind Study)

Affective disorders–such as depression, bipolar disorder, PTSD, and anxiety disorders–are some of the most prevalent and debilitating mental health conditions.  All are characterized by prominent symptoms of exaggerated negative emotions and mood states, which are known to be critically tied to the function of a brain region known as the amygdala.  A promising new method to non-invasively modulate brain function, known as focused ultrasound, has recently emerged as a cutting-edge technique to target deep brain structures (such as the amygdala) which are not otherwise reachable by standard technologies currently in clinical use.  Using low intensity, high-frequency sound waves to reach these brain areas, it may be possible to directly shift brain function to alleviate exaggerated negative emotions and mood states in individuals currently suffering from an affective disorder.

The goal of this study is to develop focused ultrasound into a new therapeutic tool for the treatment of affective disorders.

For this study we are currently looking for individuals who:

• are between the ages of 18 and 65
• Have been diagnosed with bipolar disorder, an anxiety disorder, posttraumatic stress disorder, or depression, OR do not have and have not been diagnosed with a mental health disorder and would like to be part of the mentally healthy control group
• are fluent in English
• are willing to undergo focused ultrasound and MRI procedures
• can visit the laboratory several times over the course of 2 to 6 weeks

The data collection and procedures for this study take place at the Health Discovery Building on the Dell Medical School campus.  Volunteers are able to assist with all aspects of the study process, from recruitment to data collection to data analysis and interpretation.