Neurobiology of vocalization in singing mice

This project is closed.

The Phelps lab is broadly interested in animal social behavior, its brain mechanisms, and how those mechanisms evolve. Using “exotic” rodent models, we focus on the nature and consequences of within- and between-species variation in behavior. One of our model species is the singing mouse (genus Scotinomys) of Costa Rica. These mice are named for their elaborate and audible vocalizations. While ultrasonic vocalization is common across rodents, “songs” – these elaborate vocalizations spanning ultrasonic and audible frequencies – are uniquely derived in singing mice. These songs are heavily modulated by androgens. My PhD focuses upon the evolution of the vocal brain in this species, looking at what specific brain regions androgens may influence vocal output in rodents more broadly. For this specific project, I will collaborate with a fellow graduate student on examining resulting morphology of the larynx from viral injections in this species. Briefly, we will characterize the circuitry connected to the larynx using pseudorabies virus tract tracing. To confirm accurate targeting of viral deliveries we will to run histological experiments on the muscles in the anatomical regions of interest, the cricothyroid muscle.

Student volunteers will gain exposure to a variety of approaches, ranging from cutting edge molecular methods to studies of behavior in natural environments. Lastly, the Phelps lab is a dynamic environment that allows exposure to an unusually broad range of biology.

Qualifications

The selected student will be supervised by two graduate students (David Zheng and Sam Smith). We are looking for a meticulous and responsible student who have successfully completed a course with lab components in biology at UT, such as BIO 206L. (Students who have participated in the Freshman Research Initiative are particularly encouraged to apply.) Histological techniques require great attention to details and discipline, so we care a lot about your work discipline and ability to follow guidelines for performing tasks correctly.

Project Timeline

This project is estimated to start late in September 2018 and end in January of 2019. We are looking for one student with at least 1 year to spend working in the lab. We will accept applications until the position is filled. The student will have the opportunity for more independent work once the project is completed.

Duties

We are looking for an organized, motivated volunteer who wants to assist with transcardial perfusions, cryostat sectioning, and basic microscopy. Initial tasks will be focused on training and perhaps routine maintenance of lab function. We require that students are able to attend lab meetings on Friday mornings (9:00AM-10:30AM). Work load will vary depending on the status of our breeding colony and the amount of surgeries performed. Some weeks may be busier than others. We expect a minimum commitment of 10 hours of dedicated research per week.

Typical Time Commitment
10 hours
Desired Length of Commitment
2 semesters

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