Until recently, Professor Laude maintained a research program in analytical mass spectrometry in the Department of Chemistry and Biochemistry. The program graduated 22 Ph.D. students and produced 95 refereed publications. Dr. Laude is best known for his research with Fourier transform ion cyclotron resonance mass spectrometry (FTICR). His students conducted research on fundamentals of ion motion in trapped ion cells, development of novel FTICR instrumentation and applications in analytical biochemistry. The laboratory developed a unique approach to coupling electrospray ionization with FTICR detection - the use of concentric, differential pumped vacuum chambers. The lab also worked on ion remeasurement techniques in which the same packet of ions is stabilized and remeasured hundreds of times. The group investigated the viability of open trapped ion cells for FTICR. These cells were found to possess a unique and potentially important stability region for trapping ions and permitted the first demonstration of three-dimensional ion stability in a d.c. trapping field. This approach to motional stabilization is radically different and far simpler than other methods now in use in FTICR and suggest a potentially new approach to ion trap mass spectrometry. Finally, efforts to understand the higher-order structure of gas phase biomolecules was performed using electrospray/FTICR. Techniques including H/D exchange, ion dissociation and ion mobility were used to distinguish the effects of charge and structure on gas-phase conformation.

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