The human genome is constantly attacked by endogenous and exogenous DNA-damaging agents. The Lee group seeks to understand the effects of DNA damage on DNA replication, mutations, and cancer development using combined tools of synthetic chemistry, biochemistry, and structural biology. Students interested in synthetic, biochemical, and structural biological studies of nucleic acids enzymology are encouraged to apply.
The candidate must be available for research during Fall and Spring terms (~10 hours/week) as well as summer research. Paid internships are available for qualified students.
Involve in team projects led by a graduate student or PostDoc; Express and purify proteins (e.g., DNA polymerases); Perform kinetic studies of DNA polymerases; Synthesize nucleoside analogs; A student with an excellent research performance will be given an opportunity to conduct semi-independent senior research.
