Biochemical studies of DNA damage, mutations, and carcinogenesis

This project is ongoing.

The human genome is constantly attacked by endogenous and exogenous DNA-damaging agents. The Lee group seeks to understand the effects of DNA damage on DNA replication, mutations, and cancer development using combined tools of synthetic chemistry, biochemistry, and structural biology. Students interested in synthetic, biochemical, and structural biological studies of nucleic acids enzymology are encouraged to apply. 

Project Timeline

The candidate must be available for research during Fall and Spring terms (~10 hours/week) as well as summer research. Paid internships are available for qualified students. 


Involve in team projects led by a graduate student or PostDoc; Express and purify proteins (e.g., DNA polymerases); Perform kinetic studies of DNA polymerases; Synthesize nucleoside analogs; A student with an excellent research performance will be given an opportunity to conduct semi-independent senior research.

Typical Time Commitment
Desired Length of Commitment


The Office of Undergraduate Research recommends that you attend an info session or advising before contacting faculty members or project contacts about research opportunities. We'll cover the steps to get involved, tips for contacting faculty, funding possibilities, and options for course credit. Once you have attended an Office of Undergraduate Research info session or spoken to an advisor, you can use the "Who to contact" details for this project to get in touch with the project leader and express your interest in getting involved.

Have you tried contacting professors and need more help? Schedule an appointment for additional support.