The goal of the Preston Lab is to understand the neural mechanisms that support learning and memory in the human brain. Our research focuses on how interactions between the hippocampus and prefrontal cortex promote formation of new knowledge across the lifespan. We study how these networks function in healthy adults, as well as how brain changes during development and aging impact individuals' ability to remember. Furthermore, we study how hippocampal-prefrontal memory functions support other cognitive abilities such as problem solving, creativity, reasoning, and planning abilities across the lifespan. To address these questions, the Preston Lab employs a number of techniques on the leading edge of human neuroscience, including high-resolution functional magnetic resonance imaging (fMRI), brain stimulation, intracranial recordings in human patients, and computational modeling. These techniques provide unprecedented leverage to determine not only where particular cognitive processes are instantiated in the brain, but also the precise nature of the representations and computations that give rise to them.